منابع مشابه
Detection and quantification of lupus anticoagulants in plasma from heparin treated patients, using addition of polybrene
BACKGROUND Lupus anticoagulants prolong clotting times in phospholipid-dependent coagulation tests. Lupus Ratio assays are integrated tests for lupus anticoagulants that may be based on APTT, RVVT or dPT clotting times. If a patient is being treated with unfractionated heparin, however, the heparin prolong clotting times and the diagnosis of lupus anticoagulant is invalidated. Commercial assays...
متن کاملCalibration of thromboplastins.
Anticoagulant therapy with coumarin drugs requires tests on the patient's blood to determine the dose rate for the drug. The tests involve measuring the effect of a preparation of a certain reagent, thromboplastin, in accelerating the clotting of the patient's blood. Features of the World Health Organization's recommendation on the appropriate laboratory procedure for a calibration assay and ev...
متن کاملUse of Different Tissue Thromboplastins
As anticoagulant therapy has become more widespread and a greater knowledge has been accumulated regarding the mode of action of coumarin derivatives, problems arising from the use of different thromboplastin preparations have been subjected to greater scrutiny. This paper presents an evaluation of the dependability and significance of different types of tissue thromboplastin in the determinati...
متن کاملNeutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep.
Protamine reversal of heparin anticoagulation in patients is occasionally associated with life-threatening acute pulmonary hypertension. In a sheep model, we evaluated the effect on this adverse cardiopulmonary reaction of modifying the type of heparin (low molecular weight heparin compared with unfractionated heparin) and the type of heparin antagonist (polybrene compared with protamine). Prot...
متن کاملRecombinant thromboplastins vs tissue-extract thromboplastins in patients on unstable oral anticoagulant therapy.
In a previous report in Clinical Chemistry, we described much higher international normalized ratios (INRs) with recombinant Neoplastin R (Roche Diagnostics) than with tissue-extract Neoplastin Plus (Roche Diagnostics) in patients initiating oral anticoagulant therapy (1 ). For patients on stable oral anticoagulation, we observed no significant differences in INRs between the thromboplastins. T...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 1999
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/111.4.565